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Imanis Life Sciences

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About Imanis

At Imanis, our expert scientists work to advance the development of tomorrow’s medicines by creating top-quality oncolytic viruses and noninvasive reporter gene imaging reagents. At the heart of our imaging science is NIS, the sodium iodide symporter. Our proprietary NIS reporter gene imaging technology provides unprecedented clarity in long-term cell and virus tracking studies in small and large animal models.

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What people say about Imanis

Our group has, and continues to, use NIS as a noninvasive reporter for cell transplantation studies in mice and in pigs. Imanis has provided expert technical and analytical support for this research, and has allowed us to publish our research in high impact journals, including Science Translational Medicine..

– Dr. Raymond Hickey, Mayo Clinic
 
 

Success Story

NIS is the sodium iodide symporter. It is a membrane protein that drives uptake of iodine into cells. Mammals from mouse to man express NIS endogenously in certain tissues, including the thyroid, salivary glands, gastric mucosa and mammary glands. The physiological function of NIS is to concentrate iodine in the circulation for the synthesis of thyroid hormones. NIS is a reporter gene because NIS-expressing cells concentrate radio-labeled substrates (radiotracers) and this radioactive signal can be tracked and quantified through SPECT or PET imaging. Target cells or viruses can be engineered to express NIS in order to track them noninvasively in vivo. NIS can be used in small to large animals (and humans) for longitudinal imaging studies with non-immunogenic species-specific NIS.

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