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What's the source of Imanis's transgenes?

Transgene

Accession #

Gene Source

Description

Luc2

AY738222

Photinus pyralis

Luciferase codon optimized by Promega1.

hNIS

U66088

Homo sapiens

Transient NIS expression induces iodide uptake2.

hNIS I147V

Mutant of

U66088

Homo sapiens

NIS genetically modified by Imanis for enhanced uptake.

mNIS

 AF235001

Mus musculus

Transient expression induces iodide uptake3.

rNIS

 U60282.1

Rattus norvegicus

Transient expression induces iodide uptake4.

pigNIS

 NM214410

Sus scrofa

Transient expression induces iodide uptake5.

RhNIS

N/A*

Rhesus macaque

Transient expression induces iodide uptake.

dNIS

XM_541946

Canis lupus

Transient expression induces iodide uptake6.

IRES

M81861

(nt 260 to 848)

EMCV

Independent translation of multiple proteins from a single transcript7.

eGFP

 AAB02572.1

Variant of GFP from Aequorea victoria

100-fold increase in green fluorescent signal as compared to GFP8

iRFP

JN247409

Rhodopseudomonas palustris

Near-infrared fluorescent protein: excitation = 690 emission = 713 nm9.

dsRed

 AB212907

Anopheles gambiae

Red fluorescent protein variant10

DRD2

NM_016574.3

Homo Sapiens

GPCR, dopamine receptor variant found in the brain11.

hNET

NM_001172501.1

Homo Sapiens

Sodium:neurotransmitter symporter family. Expressed by noradrenergic neurons12.

SSTR2

AY236542.1

Homo Sapiens

Somatostatin receptor. Highest expression in cerebrum and kidneys13.

HSV-TK

JQ352282.1

HSV

Human herpesvirus 1 thymidine kinase (UL23)14.

hTYR

M27160.1

Homo sapiens

Tyrosinase converts tyrosine to brown-pigmented melanin15

*Sequence derived from a cDNA library. Email info@imanislife.com for more information.
1 Promega
2 Smanik et al. Biochem Biophys Res Commun. 1996. 226(2):339-45
3 Pinke et al. Thyroid. 2001. 11(10):935-9
4 Dai et al. Nature. 1996. 379(6564):458-60
5 Selmi-Ruby et al. Endocrinology. 2003. 144(3):1074-85
6 Uyttersprot et al. Mol Cell Endocrinol. 1997. 131(2):195-203
7 Gurtu et al. Biochem Biophys Res Commun. 1996. 229(1):295-8
8 Cormack et al. Gene. 1996. 173(1):33-8
9 Filonov et al. Nat Biotechnol. 2011. 29(8):757-61
10 Baird et al. Proc Natl Acad Sci USA. 2000. 97(22):11984-9
11 Dearry et al. Cell Mol Neurobiol. 1991. 11(5):437-53
12 Pacholczyk et al. Nature. 1991. 350(6316):350-4
13 Parry et al. Mol Imaging. 2007. 6(1):56-67
14 Koehne et al. Nat Biotechnol. 2003. 21(4):405-13
15 Takeda et al. Biochem Biophys Res Commun. 1989. 162(3):984-90

 

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Use Fewer Animals

Our Reduction Campaign

At Imanis, we are committed to promoting the practice of the 3Rs in animal research. Learn how we are decreasing the use of animals and research as well as saving up to 15% on your orders. Continue reading...